42

"The answer to the ultimate question…of life, the universe, and everything is…42."
In Japanese, 4 is shi, 2 is ni. Shini means death. (shinigami=death god)

Japanese also say 4 as yon. While Yonni means nothing (I know) in Japanese, it does mean vagina in Sanskrit.
 
So the answer to the ultimate question of life, the universe, and everything, is both death...and the source of life, the vagina. Life comes from the vagina only to be later greeted by death.

Let your mind be blown by the awesomeness of Hitchhiker's Guide To The Galaxy.